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نوع الوثيقة |
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مقال في مجلة دورية |
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عنوان الوثيقة |
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Effect of cannabinoids on synaptic transmission in the rat hippocampal slice is temperature-dependent. Effect of cannabinoids on synaptic transmission in the rat hippocampal slice is temperature-dependent. |
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لغة الوثيقة |
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الانجليزية |
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المستخلص |
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Al-Hayani A, Davies SN.
Department of Biomedical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, Scotland, UK.
We have previously reported that the synthetic cannabinoid R-(+)-[2,3-dihydro-5-methyl-3-[(morpholinyl)methyl]pyrrolo[1,2,3-de]-1,4-benzoxazin-yl]-(1-naphthalenyl)methanone mesylate (WIN55,212-2) causes a selective inhibition of paired pulse depression of population spikes recorded from the CA1 region of rat hippocampal slices maintained at 28-30 degrees C. We now show that this effect is highly temperature-dependent and that WIN55,212-2 actually increases paired pulse depression of population spikes recorded from slices maintained at 35 degrees C. This temperature dependence was found to correlate with the effects of the known gamma-amino butyric acid (GABA)-uptake inhibitors, nipecotic acid and guvacine, which were without effect at 28-30 degrees C, but increased paired pulse depression at 35 degrees C. The results show that the effects of cannabinoids on synaptic transmission in the hippocampal slice are highly temperature-dependent and it is suggested that this is due to the presence of increased GABA uptake at higher temperatures.
PMID: 12020681 [PubMed - indexed for MEDLINE] |
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ردمد |
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12020681 |
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اسم الدورية |
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Eur J Pharmacol |
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المجلد |
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3 |
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العدد |
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1-2 |
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سنة النشر |
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2002 هـ
2002 م |
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نوع المقالة |
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مقالة علمية |
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تاريخ الاضافة على الموقع |
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Saturday, March 20, 2010 |
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الباحثون
| عبدالمنعم اللحياني | Al-Hayani, Abdel-Moneim | باحث | دكتوراه | |
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