تفاصيل الوثيقة نوع الوثيقة : مقال في مجلة دورية  عنوان الوثيقة : Autoantibodies to GAD and IA-2 in Saudi Arabian diabetic patients Autoantibodies to GAD and IA-2 in Saudi Arabian diabetic patients   الموضوع : السكري  لغة الوثيقة : الانجليزية  المستخلص : AIMS: To determine the prevalence of autoantibodies in sera of Saudi diabetic patients including Type 1 and Type 2 diabetes mellitus (DM) and gestational diabetes mellitus (GDM) living in Jeddah, Saudi Arabia. Apart from data on the prevalence of islet-cell antibodies in patients in Ryhadh (Al-Attas et al. Frequency of islet cell antibodies in adult newly diagnosed diabetic patients. Ann Saudi Med 1990; 10: 369-373) immunological markers of autoimmune diabetes have not been explored in Saudi Arabians. METHODS: Autoantibodies to GAD65 (GADA) and IA-2 (IA-2A) were determined using radio-immunoprecipitation assays. RESULTS: In Type 1 DM patients, 54% were GADA+ and 27% were IA-2A+. A greater negative effect of disease duration was noted for IA-2A than for GADA positivity. Autoantibodies were more prevalent with younger age of onset. GADA were slightly more common in female Type 1 DM patients. In Type 2 DM, 8/99 patients were GADA+, and three of these patients with shorter disease duration were also IA-2A+. GADA, and particularly IA-2A, were associated with a younger age of onset of Type 2 DM and all the autoantibody-positive Type 2 DM patients were insulin-treated. GADA were detected in 2.2% of GDM patients, but none of these patients possessed IA-2A. CONCLUSIONS: The prevalence and associations of autoantibodies in Saudi diabetic patients are very similar to those reported for diabetic patients in other ethnic groups  ردمد : 1464-5491  اسم الدورية : Diabetic Medicine  المجلد : 22  العدد : 4  سنة النشر : 1426 هـ 2005 م  نوع المقالة : مقالة علمية  تاريخ الاضافة على الموقع : Sunday, April 3, 2011  الباحثون اسم الباحث (عربي) اسم الباحث (انجليزي) نوع الباحث المرتبة العلمية البريد الالكتروني حسن نصرت Nasrat, Hasan باحث مشارك دكتوراه   محمد العرضاوي Ardawi, Mohammed باحث مشارك دكتوراه   الملفات اسم الملف النوع الوصف  29505.pdf pdf   الرجوع إلى صفحة الأبحاث